Molecular approaches for classifying endometrial carcinoma.
Gynecol Oncol
; 145(1): 200-207, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-28040204
ABSTRACT
Endometrial carcinoma is the most common cancer of the female genital tract. This review article discusses the usefulness of molecular techniques to classify endometrial carcinoma. Any proposal for molecular classification of neoplasms should integrate morphological features of the tumors. For that reason, we start with the current histological classification of endometrial carcinoma, by discussing the correlation between genotype and phenotype, and the most significant recent improvements. Then, we comment on some of the possible flaws of this classification, by discussing also the value of molecular pathology in improving them, including interobserver variation in pathologic interpretation of high grade tumors. Third, we discuss the importance of applying TCGA molecular approach to clinical practice. We also comment on the impact of intratumor heterogeneity in classification, and finally, we will discuss briefly, the usefulness of TCGA classification in tailoring immunotherapy in endometrial cancer patients. We suggest combining pathologic classification and the surrogate TCGA molecular classification for high-grade endometrial carcinomas, as an option to improve assessment of prognosis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA de Neoplasias
/
Neoplasias do Endométrio
/
Tumores Neuroendócrinos
/
Neoplasias Císticas, Mucinosas e Serosas
/
Carcinoma Endometrioide
/
Instabilidade de Microssatélites
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Espanha