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Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.
Kawashima, Minae; Hitomi, Yuki; Aiba, Yoshihiro; Nishida, Nao; Kojima, Kaname; Kawai, Yosuke; Nakamura, Hitomi; Tanaka, Atsushi; Zeniya, Mikio; Hashimoto, Etsuko; Ohira, Hiromasa; Yamamoto, Kazuhide; Abe, Masanori; Nakao, Kazuhiko; Yamagiwa, Satoshi; Kaneko, Shuichi; Honda, Masao; Umemura, Takeji; Ichida, Takafumi; Seike, Masataka; Sakisaka, Shotaro; Harada, Masaru; Yokosuka, Osamu; Ueno, Yoshiyuki; Senju, Michio; Kanda, Tatsuo; Shibata, Hidetaka; Himoto, Takashi; Murata, Kazumoto; Miyake, Yasuhiro; Ebinuma, Hirotoshi; Taniai, Makiko; Joshita, Satoru; Nikami, Toshiki; Ota, Hajime; Kouno, Hiroshi; Kouno, Hirotaka; Nakamuta, Makoto; Fukushima, Nobuyoshi; Kohjima, Motoyuki; Komatsu, Tatsuji; Komeda, Toshiki; Ohara, Yukio; Muro, Toyokichi; Yamashita, Tsutomu; Yoshizawa, Kaname; Nakamura, Yoko; Shimada, Masaaki; Hirashima, Noboru; Sugi, Kazuhiro.
Afiliação
  • Kawashima M; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Hitomi Y; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Aiba Y; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
  • Nishida N; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kojima K; The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
  • Kawai Y; Division of Biomedical Information Analysis, Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Nakamura H; Division of Biomedical Information Analysis, Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Tanaka A; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
  • Zeniya M; Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
  • Hashimoto E; Department of Gastroenterology and Hepatology, Tokyo Jikei University School of Medicine, Tokyo, Japan.
  • Ohira H; Department of Medicine and Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
  • Yamamoto K; Department of Gastroenterology and Rheumatic Diseases, Fukushima Medical University of Medicine, Fukushima, Japan.
  • Abe M; Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  • Nakao K; Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Matsuyama, Japan.
  • Yamagiwa S; Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagaski, Japan.
  • Kaneko S; Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
  • Honda M; Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
  • Umemura T; Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
  • Ichida T; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
  • Seike M; Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
  • Sakisaka S; First Department of Internal Medicine, Faculty of Medicine, Oita University, Oita, Japan.
  • Harada M; Department of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
  • Yokosuka O; The Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Ueno Y; Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Senju M; Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Kanda T; The Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Shibata H; Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Himoto T; Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagaski, Japan.
  • Murata K; Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Kagawa, Japan.
  • Miyake Y; The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
  • Ebinuma H; Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  • Taniai M; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio Graduate School of Medicine, Tokyo, Japan.
  • Joshita S; Department of Medicine and Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
  • Nikami T; Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
  • Ota H; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Kouno H; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Kouno H; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Nakamuta M; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Fukushima N; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Kohjima M; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Komatsu T; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Komeda T; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Ohara Y; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Muro T; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Yamashita T; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Yoshizawa K; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Nakamura Y; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Shimada M; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Hirashima N; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
  • Sugi K; Headquaters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Hum Mol Genet ; 26(3): 650-659, 2017 02 01.
Article em En | MEDLINE | ID: mdl-28062665
ABSTRACT
A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) and POU2AF1 (rs4938534) as strong susceptibility loci for PBC. In this study, we performed GWAS in additional 1,923 Japanese individuals (894 PBC cases and 1,029 healthy controls), and combined the results with the previous data. This GWAS, together with a subsequent replication study in an independent set of 7,024 Japanese individuals (512 PBC cases and 6,512 healthy controls), identified PRKCB (rs7404928) as a novel susceptibility locus for PBC (odds ratio [OR] = 1.26, P = 4.13 × 10-9). Furthermore, a primary functional variant of PRKCB (rs35015313) was identified by genotype imputation using a phased panel of 1,070 Japanese individuals from a prospective, general population cohort study and subsequent in vitro functional analyses. These results may lead to improved understanding of the disease pathways involved in PBC, forming a basis for prevention of PBC and development of novel therapeutics.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Estudo de Associação Genômica Ampla / Proteína Quinase C beta / Cirrose Hepática Biliar País/Região como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Estudo de Associação Genômica Ampla / Proteína Quinase C beta / Cirrose Hepática Biliar País/Região como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão