Conditional eQTL analysis reveals allelic heterogeneity of gene expression.
Hum Mol Genet
; 26(8): 1444-1451, 2017 04 15.
Article
em En
| MEDLINE
| ID: mdl-28165122
In recent years, multiple eQTL (expression quantitative trait loci) catalogs have become available that can help understand the functionality of complex trait-related single nucleotide polymorphisms (SNPs). In eQTL catalogs, gene expression is often strongly associated with multiple SNPs, which may reflect either one or multiple independent associations. Conditional eQTL analysis allows a distinction between dependent and independent eQTLs. We performed conditional eQTL analysis in 4,896 peripheral blood microarray gene expression samples. Our analysis showed that 35% of genes with a cis eQTL have at least two independent cis eQTLs; for several genes up to 13 independent cis eQTLs were identified. Also, 12% (671) of the independent cis eQTLs identified in conditional analyses were not significant in unconditional analyses. The number of GWAS catalog SNPs identified as eQTL in the conditional analyses increases with 24% as compared to unconditional analyses. We provide an online conditional cis eQTL mapping catalog for whole blood (https://eqtl.onderzoek.io/), which can be used to lookup eQTLs more accurately than in standard unconditional whole blood eQTL databases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sangue
/
Polimorfismo de Nucleotídeo Único
/
Locos de Características Quantitativas
/
Estudo de Associação Genômica Ampla
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Holanda