[The effect of long-term low dose prednisone on bone mineral density in patients with systemic lupus erythematosus].
Zhonghua Nei Ke Za Zhi
; 56(3): 179-183, 2017 Mar 01.
Article
em Zh
| MEDLINE
| ID: mdl-28253597
ABSTRACT
Objective:
To investigate the effect of long-term low dose prednisone administration on bone mineral density (BMD) in patients with inactive systemic lupus erythematosus (SLE).Methods:
A total of 118 inactive female SLE patients with long-term administration of low dose prednisone were recruited from the Department of Rheumatology and Immunology at An hui Provincial Hospital.All patients were given low dose prednisone for long-term (≤10 mg/d, more than half a year). According to prednisone doses, subjects were divided into two groups, namely group A (≤7.5 mg/d) and group B (7.5-10 mg/d). In addition, patients were also divided into four groups based on the duration of administration, including groupâ ≤3 years, â ¡from 4-5 years, â ¢ 6-10 years and â £>10 years.Twenty-nine healthy people were recruitedas normal controls.The BMD was measured by dual energy X-ray absorptiometry.The association of BMD with prednisone dose and duration was compared between different groups.Results:
The incidence of osteopenia in all patients with SLE was 42.4%(50/118), and the incidence of osteoporosis was 14.4%(17/118). BMD of all bone sites in both group A and B were significantly lower than that in normal control group (P<0.05). Similarly, the BMD of all bone sites in groupâ , â ¡, â ¢ and â £ were significantly decreased (P<0.05). What needed to be stressed was the BMD in group â £ was lower than those in other three groups (P<0.05). Multiple logistic regression analysis showed that the cumulative prednisone dose was the risk factor for osteopenia, while taking calcium and alfacalcidol were protective factors.Conclusion:
Long-term use of low dose prednisone result in the decrease of BMD in patients with inactive SLE.The lumbar spine and femoral neck had more severe osteopenia. Long-term administration of prednisone, even less than 7.5 mg/d, can also cause osteopenia.Calcium and alfacalcidol were protective factors of BMD.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Prednisona
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Densidade Óssea
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Glucocorticoides
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Lúpus Eritematoso Sistêmico
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China