mTOR Signaling in Growth, Metabolism, and Disease.

Saxton, Robert A; Sabatini, David M

Saxton, Robert A; Sabatini, David M.

Afiliação

Saxton RA; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA.
Sabatini DM; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: sabatini@wi.mit.edu.

Cell ; 168(6): 960-976, 2017 03 09.

Article em En | MEDLINE | ID: mdl-28283069

Assuntos

Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Envelhecimento/metabolismo; Animais; Diabetes Mellitus/metabolismo; Glucose/metabolismo; Humanos; Músculos/metabolismo; Neoplasias/metabolismo

Palavras-chave

aging; cancer; cell growth; diabetes; mTOR; mTORC1; mTORC2; metabolism; nutrients; signaling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Serina-Treonina Quinases TOR Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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