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Synthetic Biology: Engineering Living Systems from Biophysical Principles.
Bartley, Bryan A; Kim, Kyung; Medley, J Kyle; Sauro, Herbert M.
Afiliação
  • Bartley BA; Department of Bioengineering, University of Washington, Seattle, Washington.
  • Kim K; Department of Bioengineering, University of Washington, Seattle, Washington.
  • Medley JK; Department of Bioengineering, University of Washington, Seattle, Washington.
  • Sauro HM; Department of Bioengineering, University of Washington, Seattle, Washington. Electronic address: hsauro@u.washington.edu.
Biophys J ; 112(6): 1050-1058, 2017 Mar 28.
Article em En | MEDLINE | ID: mdl-28355534
Synthetic biology was founded as a biophysical discipline that sought explanations for the origins of life from chemical and physical first principles. Modern synthetic biology has been reinvented as an engineering discipline to design new organisms as well as to better understand fundamental biological mechanisms. However, success is still largely limited to the laboratory and transformative applications of synthetic biology are still in their infancy. Here, we review six principles of living systems and how they compare and contrast with engineered systems. We cite specific examples from the synthetic biology literature that illustrate these principles and speculate on their implications for further study. To fully realize the promise of synthetic biology, we must be aware of life's unique properties.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenômenos Biofísicos / Biologia Sintética Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenômenos Biofísicos / Biologia Sintética Idioma: En Ano de publicação: 2017 Tipo de documento: Article