High level of IL-10 expression in the blood of animal models possibly relates to resistance against leptospirosis.
Cytokine
; 96: 144-151, 2017 08.
Article
em En
| MEDLINE
| ID: mdl-28410507
ABSTRACT
Leptospirosis is a severe zoonosis which immunopathogenesis is poorly understood. We evaluated correlation between acute form of the disease and the ratio of the anti-inflammatory cytokine IL-10 to the pro-inflammatory TNF-α and IL-1ß expression during the early phase of infection comparing resistant mice and susceptible hamsters infected with two different species of virulent Leptospira. The IL-10/TNF-α and IL-10/IL-1ß expression ratios were higher in mouse compared to hamster independently of the Leptospira strain, suggesting a preponderant role of the host response and notably these cytokines in the clinical expression and survival to leptospirosis. Using an IL-10 neutralization strategy in Leptospira-infected mouse model, we also showed evidence of a possible role of this cytokine on host susceptibility, bacterial clearance and on regulation of cytokine gene expression.
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Base de dados:
MEDLINE
Assunto principal:
Interleucina-10
/
Leptospirose
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article