Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on TrkB.

Guo, Yun-Yun; Lu, Yi; Zheng, Yuan; Chen, Xiao-Rong; Dong, Jun-Lu; Yuan, Rong-Rong; Huang, Shu-Hong; Yu, Hui; Wang, Yue; Chen, Zhe-Yu; Su, Bo

Guo, Yun-Yun; Lu, Yi; Zheng, Yuan; Chen, Xiao-Rong; Dong, Jun-Lu; Yuan, Rong-Rong; Huang, Shu-Hong; Yu, Hui; Wang, Yue; Chen, Zhe-Yu; Su, Bo.

Afiliação

Guo YY; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and.
Lu Y; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and.
Zheng Y; Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, 250012, P.R. China.
Chen XR; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and.
Dong JL; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and.
Yuan RR; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and.
Huang SH; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and.
Yu H; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and.
Wang Y; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and.
Chen ZY; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and.
Su B; Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, and bxs103@sdu.edu.cn.

J Neurosci ; 37(25): 5978-5995, 2017 06 21.

Article em En | MEDLINE | ID: mdl-28500221

Assuntos

Hipocampo/fisiologia; Memória/fisiologia; Receptor trkB/metabolismo; Ubiquitina Tiolesterase/metabolismo; Ubiquitinação/fisiologia; Animais; Azepinas/farmacologia; Benzamidas/farmacologia; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Fator Neurotrófico Derivado do Encéfalo/farmacologia; Condicionamento Operante/fisiologia; Endocitose/genética; Endocitose/fisiologia; Medo/psicologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Atividade Motora/efeitos dos fármacos; Atividade Motora/genética; Atividade Motora/fisiologia; Neurônios/metabolismo; Receptor trkB/antagonistas & inibidores; Transdução de Sinais/genética; Transdução de Sinais/fisiologia; Ubiquitina Tiolesterase/genética; Ubiquitinação/genética

Palavras-chave

TrkB; UCHL1; endocytosis; learning and memory; recycling; ubiquitination

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor trkB / Ubiquitina Tiolesterase / Ubiquitinação / Hipocampo / Memória Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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