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The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins.
Dreser, Alice; Vollrath, Jan Tilmann; Sechi, Antonio; Johann, Sonja; Roos, Andreas; Yamoah, Alfred; Katona, Istvan; Bohlega, Saeed; Wiemuth, Dominik; Tian, Yuemin; Schmidt, Axel; Vervoorts, Jörg; Dohmen, Marc; Beyer, Cordian; Anink, Jasper; Aronica, Eleonora; Troost, Dirk; Weis, Joachim; Goswami, Anand.
Afiliação
  • Dreser A; Institute of Neuropathology, RWTH Aachen University Medical School, Aachen, Germany.
  • Vollrath JT; Institute of Neuropathology, RWTH Aachen University Medical School, Aachen, Germany.
  • Sechi A; Institute of Biomedical Engineering, Deparment of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.
  • Johann S; Institute of Neuroanatomy, RWTH Aachen University Medical School, Aachen, Germany.
  • Roos A; Institute of Neuropathology, RWTH Aachen University Medical School, Aachen, Germany.
  • Yamoah A; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany.
  • Katona I; Institute of Genetic Medicine, John Walton Muscular Dystrophy Research Centre, International Centre for Life, Central Parkway, Newcastle upon Tyne, England, UK.
  • Bohlega S; Institute of Neuropathology, RWTH Aachen University Medical School, Aachen, Germany.
  • Wiemuth D; Institute of Neuropathology, RWTH Aachen University Medical School, Aachen, Germany.
  • Tian Y; Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  • Schmidt A; Institute of Physiology, RWTH Aachen University Medical School, Aachen Germany.
  • Vervoorts J; Institute of Physiology, RWTH Aachen University Medical School, Aachen Germany.
  • Dohmen M; Institute of Physiology, RWTH Aachen University Medical School, Aachen Germany.
  • Beyer C; Institute of Biochemistry and Molecular Biology, RWTH Aachen University Medical School, Aachen, Germany.
  • Anink J; Institute of Biochemistry and Molecular Biology, RWTH Aachen University Medical School, Aachen, Germany.
  • Aronica E; Institute of Neuroanatomy, RWTH Aachen University Medical School, Aachen, Germany.
  • Troost D; Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • Weis J; Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • Goswami A; Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Cell Death Differ ; 24(10): 1655-1671, 2017 10.
Article em En | MEDLINE | ID: mdl-28622300
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a RNA / Receptores sigma / Estresse do Retículo Endoplasmático / Homeostase / Esclerose Lateral Amiotrófica / Mutação Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a RNA / Receptores sigma / Estresse do Retículo Endoplasmático / Homeostase / Esclerose Lateral Amiotrófica / Mutação Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha