Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.
Cell
; 170(1): 185-198.e16, 2017 Jun 29.
Article
em En
| MEDLINE
| ID: mdl-28648659
ABSTRACT
Dietary, microbial, and inflammatory factors modulate the gut-brain axis and influence physiological processes ranging from metabolism to cognition. The gut epithelium is a principal site for detecting such agents, but precisely how it communicates with neural elements is poorly understood. Serotonergic enterochromaffin (EC) cells are proposed to fulfill this role by acting as chemosensors, but understanding how these rare and unique cell types transduce chemosensory information to the nervous system has been hampered by their paucity and inaccessibility to single-cell measurements. Here, we circumvent this limitation by exploiting cultured intestinal organoids together with single-cell measurements to elucidate intrinsic biophysical, pharmacological, and genetic properties of EC cells. We show that EC cells express specific chemosensory receptors, are electrically excitable, and modulate serotonin-sensitive primary afferent nerve fibers via synaptic connections, enabling them to detect and transduce environmental, metabolic, and homeostatic information from the gut directly to the nervous system.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Quimiorreceptoras
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Trato Gastrointestinal
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Células Enterocromafins
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Vias Neurais
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos