Metabolite profiling in early clinical drug development: current status and future prospects.

Ufer, Mike; Juif, Pierre-Eric; Boof, Marie-Laure; Muehlan, Clemens; Dingemanse, Jasper

Ufer, Mike; Juif, Pierre-Eric; Boof, Marie-Laure; Muehlan, Clemens; Dingemanse, Jasper.

Afiliação

Ufer M; a Department of Clinical Pharmacology , Idorsia Pharmaceuticals Ltd , Allschwil , Switzerland.
Juif PE; a Department of Clinical Pharmacology , Idorsia Pharmaceuticals Ltd , Allschwil , Switzerland.
Boof ML; a Department of Clinical Pharmacology , Idorsia Pharmaceuticals Ltd , Allschwil , Switzerland.
Muehlan C; a Department of Clinical Pharmacology , Idorsia Pharmaceuticals Ltd , Allschwil , Switzerland.
Dingemanse J; a Department of Clinical Pharmacology , Idorsia Pharmaceuticals Ltd , Allschwil , Switzerland.

Expert Opin Drug Metab Toxicol ; 13(8): 803-806, 2017 08.

Article em En | MEDLINE | ID: mdl-28689432

Assuntos

Desenho de Fármacos; Metabolômica/métodos; Preparações Farmacêuticas/metabolismo; Farmacocinética; Animais; Interações Medicamentosas; Humanos

Palavras-chave

Metabolite profiling; drug development; human ADME; metabolomics; micro-dose; micro-tracer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Farmacocinética / Preparações Farmacêuticas / Desenho de Fármacos / Metabolômica Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Suíça

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