Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.

Thomas, James D; Sznajder, Lukasz J; Bardhi, Olgert; Aslam, Faaiq N; Anastasiadis, Zacharias P; Scotti, Marina M; Nishino, Ichizo; Nakamori, Masayuki; Wang, Eric T; Swanson, Maurice S

Thomas, James D; Sznajder, Lukasz J; Bardhi, Olgert; Aslam, Faaiq N; Anastasiadis, Zacharias P; Scotti, Marina M; Nishino, Ichizo; Nakamori, Masayuki; Wang, Eric T; Swanson, Maurice S.

Afiliação

Thomas JD; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.
Sznajder LJ; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.
Bardhi O; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.
Aslam FN; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.
Anastasiadis ZP; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.
Scotti MM; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.
Nishino I; Department of Neuromuscular Research, National Center of Neurology and Psychiatry, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Nakamori M; Department of Neurology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Wang ET; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.
Swanson MS; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

Genes Dev ; 31(11): 1122-1133, 2017 06 01.

Article em En | MEDLINE | ID: mdl-28698297

Assuntos

Desenvolvimento Muscular/genética; Distrofia Miotônica/genética; Distrofia Miotônica/fisiopatologia; Processamento Pós-Transcricional do RNA/genética; Splicing de RNA; Proteínas de Ligação a RNA/genética; Animais; Proteínas de Transporte/genética; Células Cultivadas; Pré-Escolar; Proteínas de Ligação a DNA/genética; Modelos Animais de Doenças; Perfilação da Expressão Gênica; Regulação da Expressão Gênica no Desenvolvimento/genética; Técnicas de Inativação de Genes; Humanos; Lactente; Camundongos; Proteínas de Ligação a RNA/metabolismo

Palavras-chave

MBNL; RNA processing; congenital myotonic dystrophy; microsatellite; myoblast; myogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento Pós-Transcricional do RNA / Splicing de RNA / Proteínas de Ligação a RNA / Desenvolvimento Muscular / Distrofia Miotônica Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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