Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage.
Cell Rep
; 20(5): 1061-1072, 2017 08 01.
Article
em En
| MEDLINE
| ID: mdl-28768192
ABSTRACT
The epidermis is a highly regenerative barrier protecting organisms from environmental insults, including UV radiation, the main cause of skin cancer and skin aging. Here, we show that time-restricted feeding (RF) shifts the phase and alters the amplitude of the skin circadian clock and affects the expression of approximately 10% of the skin transcriptome. Furthermore, a large number of skin-expressed genes are acutely regulated by food intake. Although the circadian clock is required for daily rhythms in DNA synthesis in epidermal progenitor cells, RF-induced shifts in clock phase do not alter the phase of DNA synthesis. However, RF alters both diurnal sensitivity to UVB-induced DNA damage and expression of the key DNA repair gene, Xpa. Together, our findings indicate regulation of skin function by time of feeding and emphasize a link between circadian rhythm, food intake, and skin health.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pele
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Raios Ultravioleta
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Dano ao DNA
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Ritmo Circadiano
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Ingestão de Alimentos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article