Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection.
Virol J
; 14(1): 162, 2017 08 22.
Article
em En
| MEDLINE
| ID: mdl-28830486
ABSTRACT
Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010-2011 influenza seasons, nearly half of the circulating H3N2 IAVs encoded truncated PB1-F2 protein. Using a panel of reverse engineered H3N2 IAVs differing only in the origin of the PB1 gene segment, we found that only the virus encoding the avian-derived 1968 PB1 gene matching the human pandemic strain enhanced cellular infiltrate into the alveolar spaces of infected mice. We linked this phenomenon to expression of full-length PB1-F2 protein encompassing critical "inflammatory" residues.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
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Virulência
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Regulação Viral da Expressão Gênica
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Vírus da Influenza A Subtipo H3N2
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Austrália