ESCRT genes and regulation of developmental signaling.
Semin Cell Dev Biol
; 74: 29-39, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-28847745
ABSTRACT
ESCRT (Endosomal Sorting Complex Required for Transport) proteins have been shown to control an increasing number of membrane-associated processes. Some of these, and prominently regulation of receptor trafficking, profoundly shape signal transduction. Evidence in fungi, plants and multiple animal models support the emerging concept that ESCRTs are main actors in coordination of signaling with the changes in cells and tissues occurring during development and homeostasis. Consistent with their pleiotropic function, ESCRTs are regulated in multiple ways to tailor signaling to developmental and homeostatic needs. ESCRT activity is crucial to correct execution of developmental programs, especially at key transitions, allowing eukaryotes to thrive and preventing appearance of congenital defects.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Complexos Endossomais de Distribuição Requeridos para Transporte
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Itália