Reading chromatin signatures after DNA double-strand breaks.
Philos Trans R Soc Lond B Biol Sci
; 372(1731)2017 Oct 05.
Article
em En
| MEDLINE
| ID: mdl-28847817
ABSTRACT
DNA double-strand breaks (DSBs) are DNA lesions that must be accurately repaired in order to preserve genomic integrity and cellular viability. The response to DSBs reshapes the local chromatin environment and is largely orchestrated by the deposition, removal and detection of a complex set of chromatin-associated post-translational modifications. In particular, the nucleosome acts as a central signalling hub and landing platform in this process by organizing the recruitment of repair and signalling factors, while at the same time coordinating repair with other DNA-based cellular processes. While current research has provided a descriptive overview of which histone marks affect DSB repair, we are only beginning to understand how these marks are interpreted to foster an efficient DSB response. Here we review how the modified chromatin surrounding DSBs is read, with a focus on the insights gleaned from structural and biochemical studies.This article is part of the themed issue 'Chromatin modifiers and remodellers in DNA repair and signalling'.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Processamento de Proteína Pós-Traducional
/
Quebras de DNA de Cadeia Dupla
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido