The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis.

Kimura, Hirotaka; Matsuyama, Yasushi; Araki, Sachiko; Koizumi, Atsushi; Kariya, Yumi; Takasuga, Shunsuke; Eguchi, Satoshi; Nakanishi, Hiroki; Sasaki, Junko; Sasaki, Takehiko

Kimura, Hirotaka; Matsuyama, Yasushi; Araki, Sachiko; Koizumi, Atsushi; Kariya, Yumi; Takasuga, Shunsuke; Eguchi, Satoshi; Nakanishi, Hiroki; Sasaki, Junko; Sasaki, Takehiko.

Afiliação

Kimura H; a Department of Medical Biology , Akita University Graduate School of Medicine , Akita , Japan.
Matsuyama Y; b Research Center for Biosignaling , Akita University , Akita , Japan.
Araki S; c Medical Educational Center , Jichi Medical University , Tochigi , Japan.
Koizumi A; d Department of Internal Medicine, Division of Rheumatology and Clinical Immunology , Jichi Medical University , Tochigi , Japan.
Kariya Y; e Department of Internal Medicine , Niizashiki Central General Hospital , Saitama , Japan.
Takasuga S; f Department of Urology , Akita University Graduate School of Medicine , Akita , Japan.
Eguchi S; a Department of Medical Biology , Akita University Graduate School of Medicine , Akita , Japan.
Nakanishi H; a Department of Medical Biology , Akita University Graduate School of Medicine , Akita , Japan.
Sasaki J; a Department of Medical Biology , Akita University Graduate School of Medicine , Akita , Japan.
Sasaki T; b Research Center for Biosignaling , Akita University , Akita , Japan.

Mod Rheumatol ; 28(3): 530-541, 2018 May.

Article em En | MEDLINE | ID: mdl-28880680

Assuntos

Anticorpos Anticitoplasma de Neutrófilos/metabolismo; Armadilhas Extracelulares/metabolismo; Poliangiite Microscópica/metabolismo; Fosfatidilinositol 3-Quinases/deficiência; Animais; Produtos Biológicos/toxicidade; Candida/química; Armadilhas Extracelulares/efeitos dos fármacos; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Poliangiite Microscópica/etiologia; Inibidores de Fosfoinositídeo-3 Quinase; Inibidores de Proteínas Quinases/farmacologia

Palavras-chave

Animal model; anti-neutrophil cytoplasmic antibody; microscopic polyangiitis; neutrophil extracellular traps; phosphoinositide 3-kinase gamma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Anticitoplasma de Neutrófilos / Fosfatidilinositol 3-Quinases / Poliangiite Microscópica / Armadilhas Extracelulares Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão

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