Repeatability of tumour hypoxia imaging using [18F]EF5 PET/CT in head and neck cancer.
Eur J Nucl Med Mol Imaging
; 45(2): 161-169, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29075831
ABSTRACT
PURPOSE:
Hypoxia contributes to radiotherapy resistance and more aggressive behaviour of several types of cancer. This study was designed to evaluate the repeatability of intratumour uptake of the hypoxia tracer [18F]EF5 in paired PET/CT scans.METHODS:
Ten patients with newly diagnosed head and neck cancer (HNC) received three static PET/CT scans before chemoradiotherapy two with [18F]EF5 a median of 7 days apart and one with [18F]FDG. Metabolically active primary tumour volumes were defined in [18F]FDG images and transferred to co-registered [18F]EF5 images for repeatability analysis. A tumour-to-muscle uptake ratio (TMR) of 1.5 at 3 h from injection of [18F]EF5 was used as a threshold representing hypoxic tissue.RESULTS:
In 10 paired [18F]EF5 PET/CT image sets, SUVmean, SUVmax, and TMR showed a good correlation with the intraclass correlation coefficients of 0.81, 0.85, and 0.87, respectively. The relative coefficients of repeatability for these parameters were 15%, 17%, and 10%, respectively. Fractional hypoxic volumes of the tumours in the repeated scans had a high correlation using the Spearman rank correlation test (r = 0.94). In a voxel-by-voxel TMR analysis between the repeated scans, the mean of Pearson correlation coefficients of individual patients was 0.65. The mean (± SD) difference of TMR in the pooled data set was 0.03 ± 0.20.CONCLUSION:
Pretreatment [18F]EF5 PET/CT within one week shows high repeatability and is feasible for the guiding of hypoxia-targeted treatment interventions in HNC.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Radioisótopos de Flúor
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Etanidazol
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Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
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Hipóxia Tumoral
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Neoplasias de Cabeça e Pescoço
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Hidrocarbonetos Fluorados
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Finlândia