Recombinant human GLP-1(rhGLP-1) alleviating renal tubulointestitial injury in diabetic STZ-induced rats.

Yin, Weiqin; Xu, Shiqing; Wang, Zai; Liu, Honglin; Peng, Liang; Fang, Qing; Deng, Tingting; Zhang, Wenjian; Lou, Jinning

Yin, Weiqin; Xu, Shiqing; Wang, Zai; Liu, Honglin; Peng, Liang; Fang, Qing; Deng, Tingting; Zhang, Wenjian; Lou, Jinning.

Afiliação

Yin W; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, PR China.
Xu S; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China.
Wang Z; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China.
Liu H; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China.
Peng L; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China.
Fang Q; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China.
Deng T; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China.
Zhang W; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China. Electronic address: zwj-72@163.com.
Lou J; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, PR China. Electronic address: lou_jn@163.com.

Biochem Biophys Res Commun ; 495(1): 793-800, 2018 01 01.

Article em En | MEDLINE | ID: mdl-29137984

Assuntos

Nefropatias Diabéticas/tratamento farmacológico; Nefropatias Diabéticas/metabolismo; Nefropatias Diabéticas/patologia; Peptídeo 1 Semelhante ao Glucagon/uso terapêutico; Nefrite Intersticial/tratamento farmacológico; Nefrite Intersticial/metabolismo; Animais; Diabetes Mellitus Experimental/tratamento farmacológico; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Peptídeo 1 Semelhante ao Glucagon/genética; Humanos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; NF-kappa B/metabolismo; Nefrite Intersticial/patologia; Ratos; Proteínas Recombinantes/uso terapêutico; Resultado do Tratamento

Palavras-chave

Diabetic nephropathy; Fibrosis; Inflammation; Recombinant human GLP-1 (rhGLP-1); Renal tubulointerstitial injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nefropatias Diabéticas / Peptídeo 1 Semelhante ao Glucagon / Nefrite Intersticial Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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