NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.

Swarbrick, Crystall M D; Basavannacharya, Chandrakala; Chan, Kitti W K; Chan, Shu-Ann; Singh, Daljit; Wei, Na; Phoo, Wint Wint; Luo, Dahai; Lescar, Julien; Vasudevan, Subhash G

Swarbrick, Crystall M D; Basavannacharya, Chandrakala; Chan, Kitti W K; Chan, Shu-Ann; Singh, Daljit; Wei, Na; Phoo, Wint Wint; Luo, Dahai; Lescar, Julien; Vasudevan, Subhash G.

Afiliação

Swarbrick CMD; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore.
Basavannacharya C; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore.
Chan KWK; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore.
Chan SA; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, 117545, Singapore.
Singh D; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore.
Wei N; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore.
Phoo WW; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore.
Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, 138673, Singapore.
Lescar J; Nanyang Institute for Structural Biology, School of Biological Sciences, Nanyang Technological University, 138673, Singapore.
Vasudevan SG; Lee Kong Chian School of Medicine, Nanyang Technological University, 138673, Singapore.

Nucleic Acids Res ; 45(22): 12904-12920, 2017 Dec 15.

Article em En | MEDLINE | ID: mdl-29165589

Assuntos

Vírus da Dengue/metabolismo; RNA Viral/metabolismo; Proteínas não Estruturais Virais/metabolismo; Replicação Viral; Adenosina Trifosfatases/genética; Adenosina Trifosfatases/metabolismo; Animais; Linhagem Celular; Vírus da Dengue/genética; Cinética; Modelos Moleculares; Mutação; Conformação de Ácido Nucleico; Ligação Proteica; Domínios Proteicos; RNA Helicases/química; RNA Helicases/genética; RNA Helicases/metabolismo; RNA Viral/química; RNA Viral/genética; Serina Endopeptidases/química; Serina Endopeptidases/genética; Serina Endopeptidases/metabolismo; Termodinâmica; Proteínas não Estruturais Virais/química; Proteínas não Estruturais Virais/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / RNA Viral / Proteínas não Estruturais Virais / Vírus da Dengue Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Singapura

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