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Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival.
Segatto, Marco; Fittipaldi, Raffaella; Pin, Fabrizio; Sartori, Roberta; Dae Ko, Kyung; Zare, Hossein; Fenizia, Claudio; Zanchettin, Gianpietro; Pierobon, Elisa Sefora; Hatakeyama, Shinji; Sperti, Cosimo; Merigliano, Stefano; Sandri, Marco; Filippakopoulos, Panagis; Costelli, Paola; Sartorelli, Vittorio; Caretti, Giuseppina.
Afiliação
  • Segatto M; Department of Biosciences, Universita' degli Studi di Milano, Via Celoria 26, 20133, Milan, Italy.
  • Fittipaldi R; Department of Biosciences, Universita' degli Studi di Milano, Via Celoria 26, 20133, Milan, Italy.
  • Pin F; Department of Clinical and Biological Sciences, Unit of General and Clinical Pathology, University of Turin, 10124, Torino, Italy.
  • Sartori R; Department of Biomedical Sciences, University of Padova, 35131, Padova, Italy.
  • Dae Ko K; Venetian Institute of Molecular Medicine, 35131, Padova, Italy.
  • Zare H; Laboratory of Muscle Stem Cells and Gene Regulation, NIH/NIAMS, 50 South Drive, Bethesda, MD, USA.
  • Fenizia C; Laboratory of Muscle Stem Cells and Gene Regulation, NIH/NIAMS, 50 South Drive, Bethesda, MD, USA.
  • Zanchettin G; Department of Biosciences, Universita' degli Studi di Milano, Via Celoria 26, 20133, Milan, Italy.
  • Pierobon ES; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, 35122, Padova, Italy.
  • Hatakeyama S; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, 35122, Padova, Italy.
  • Sperti C; Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research Basel, Novartis Pharma AG, 4056, Basel, Switzerland.
  • Merigliano S; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, 35122, Padova, Italy.
  • Sandri M; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, 35122, Padova, Italy.
  • Filippakopoulos P; Venetian Institute of Molecular Medicine, 35131, Padova, Italy.
  • Costelli P; Laboratory of Muscle Stem Cells and Gene Regulation, NIH/NIAMS, 50 South Drive, Bethesda, MD, USA.
  • Sartorelli V; Structural Genomics Consortium, Old Road Campus Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
  • Caretti G; Ludwig Institute for Cancer Research, Old Road Campus Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Nat Commun ; 8(1): 1707, 2017 11 22.
Article em En | MEDLINE | ID: mdl-29167426
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Caquexia / Proteínas Nucleares / Neoplasias Experimentais Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Caquexia / Proteínas Nucleares / Neoplasias Experimentais Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália