Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathy.

Hsu, Yu-Juei; Hsu, Shih-Che; Chang, Yung-Lung; Huang, Shih-Ming; Shih, Chun-Che; Tsai, Chien-Sung; Lin, Chih-Yuan

Hsu, Yu-Juei; Hsu, Shih-Che; Chang, Yung-Lung; Huang, Shih-Ming; Shih, Chun-Che; Tsai, Chien-Sung; Lin, Chih-Yuan.

Afiliação

Hsu YJ; Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
Hsu SC; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
Chang YL; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
Huang SM; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
Shih CC; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Tsai CS; Superintendent's Office, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan; Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Lin CY; Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address: linrock@ms26.hinet.net.

Int J Cardiol ; 252: 128-135, 2018 Feb 01.

Article em En | MEDLINE | ID: mdl-29203210

Assuntos

Fator 3 Ativador da Transcrição/biossíntese; Cardiomiopatias/metabolismo; Indicã/farmacologia; Proteínas Quinases JNK Ativadas por Mitógeno/biossíntese; Receptor CB1 de Canabinoide/biossíntese; Uremia/metabolismo; Animais; Linhagem Celular; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Ratos; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/fisiologia; Regulação para Cima/efeitos dos fármacos; Regulação para Cima/fisiologia

Palavras-chave

ATF3; C-Jun; Cannabinoid type 1 receptor; Indoxyl sulfate; Oxidative stress; Uremic cardiomyopathy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Uremia / Receptor CB1 de Canabinoide / Proteínas Quinases JNK Ativadas por Mitógeno / Fator 3 Ativador da Transcrição / Indicã / Cardiomiopatias Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Taiwan

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