Design, synthesis and evaluation of an anthraquinone derivative conjugated to myelin basic protein immunodominant (MBP<sub>85-99</sub>) epitope: Towards selective immunosuppression.

Tapeinou, Anthi; Giannopoulou, Efstathia; Simal, Carmen; Hansen, Bjarke E; Kalofonos, Haralabos; Apostolopoulos, Vasso; Vlamis-Gardikas, Alexios; Tselios, Theodore

Design, synthesis and evaluation of an anthraquinone derivative conjugated to myelin basic protein immunodominant (MBP_85-99) epitope: Towards selective immunosuppression.

Tapeinou, Anthi; Giannopoulou, Efstathia; Simal, Carmen; Hansen, Bjarke E; Kalofonos, Haralabos; Apostolopoulos, Vasso; Vlamis-Gardikas, Alexios; Tselios, Theodore.

Afiliação

Tapeinou A; Department of Chemistry, University of Patras, GR-26504, Rion, Greece.
Giannopoulou E; Clinical Oncology Laboratory, University Hospital of Patras, Patras Medical School, GR-26504, Rion, Greece.
Simal C; Department of Chemistry, University of Patras, GR-26504, Rion, Greece.
Hansen BE; Institute for Inflammation Research, Department of Infectious Diseases and Rheumatology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
Kalofonos H; Clinical Oncology Laboratory, University Hospital of Patras, Patras Medical School, GR-26504, Rion, Greece.
Apostolopoulos V; Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia.
Vlamis-Gardikas A; Department of Chemistry, University of Patras, GR-26504, Rion, Greece. Electronic address: avlamis@upatras.gr.
Tselios T; Department of Chemistry, University of Patras, GR-26504, Rion, Greece. Electronic address: ttselios@upatras.gr.

Eur J Med Chem ; 143: 621-631, 2018 Jan 01.

Article em En | MEDLINE | ID: mdl-29216561

Assuntos

Antraquinonas/farmacologia; Desenho de Fármacos; Epitopos/farmacologia; Terapia de Imunossupressão; Proteína Básica da Mielina/farmacologia; Fragmentos de Peptídeos/farmacologia; Linfócitos T/efeitos dos fármacos; Antraquinonas/síntese química; Antraquinonas/química; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Relação Dose-Resposta a Droga; Epitopos/química; Células HEK293; Humanos; Células Jurkat; Estrutura Molecular; Proteína Básica da Mielina/química; Fragmentos de Peptídeos/química; Relação Estrutura-Atividade

Palavras-chave

Epitope; MBP; Multiple sclerosis; Myelin basic protein; Peptide-MHC-TCR interaction; Quinizarin derivatives; Selective immunosuppression; Thioredoxin; Trimolecular complex

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Linfócitos T / Desenho de Fármacos / Antraquinonas / Terapia de Imunossupressão / Proteína Básica da Mielina / Epitopos Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Grécia

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