Monocytic myeloid-derived suppressor cells as prognostic factor in chronic myeloid leukaemia patients treated with dasatinib.
J Cell Mol Med
; 22(2): 1070-1080, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29218828
ABSTRACT
Myeloid suppressor cells are a heterogeneous group of myeloid cells that are increased in patients with chronic myeloid leukaemia (CML) inducing T cell tolerance. In this study, we found that therapy with tyrosine kinase inhibitors (TKI) decreased the percentage of granulocytic MDSC, but only patients treated with dasatinib showed a significant reduction in the monocytic subset (M-MDSC). Moreover, a positive correlation was observed between number of persistent M-MDSC and the value of major molecular response in dasatinib-treated patients. Serum and exosomes from patients with CML induced conversion of monocytes from healthy volunteers into immunosuppressive M-MDSC, suggesting a bidirectional crosstalk between CML cells and MDSC. Overall, we identified M-MDSC as prognostic factors in patients treated with dasatinib. It might be of interest to understand whether MDSC may be a candidate predictive markers of relapse risk following TKI discontinuation, suggesting their potential significance as practice of precision medicine.
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Base de dados:
MEDLINE
Assunto principal:
Monócitos
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Leucemia Mielogênica Crônica BCR-ABL Positiva
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Dasatinibe
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Células Supressoras Mieloides
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Itália