Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue-engineered skin equivalents.

Smith, Sarah A; Colley, Helen E; Sharma, Parveen; Slowik, Klaudia M; Sison-Young, Rowena; Sneddon, Andrew; Webb, Steven D; Murdoch, Craig

Smith, Sarah A; Colley, Helen E; Sharma, Parveen; Slowik, Klaudia M; Sison-Young, Rowena; Sneddon, Andrew; Webb, Steven D; Murdoch, Craig.

Afiliação

Smith SA; School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Colley HE; School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Sharma P; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Slowik KM; School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Sison-Young R; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Sneddon A; Department of Applied Mathematics, Liverpool John Moores University, Liverpool, UK.
Webb SD; Department of Applied Mathematics, Liverpool John Moores University, Liverpool, UK.
Murdoch C; School of Clinical Dentistry, University of Sheffield, Sheffield, UK.

Exp Dermatol ; 27(5): 473-475, 2018 05.

Article em En | MEDLINE | ID: mdl-29227563

Assuntos

Citocromo P-450 CYP3A/metabolismo; Modelos Biológicos; Pele/enzimologia; Humanos; Fígado/enzimologia; Engenharia Tecidual

Palavras-chave

epithelium; steroids; three-dimensional tissue models; toxicity; xenobiotic metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Citocromo P-450 CYP3A / Modelos Biológicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

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