Evaluation of mapping biopsies for extramammary Paget disease: A retrospective study.
J Am Acad Dermatol
; 78(6): 1171-1177.e4, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29277730
ABSTRACT
BACKGROUND:
Extramammary Paget disease (EMPD) sometimes shows an ill-defined border and an unexpectedly extended tumor spread beyond the clinical borders. Mapping biopsy is 1 approach for complete surgical removal, but its efficacy has remained controversial.OBJECTIVE:
We sought to evaluate mapping biopsies for EMPD.METHODS:
We performed a retrospective review of 133 patients with 150 primary EMPD lesions. We histopathologically examined 1182 skin biopsy specimens (975 from mapping biopsy and 207 from lesional biopsy).RESULTS:
Only 1.6% of mapping biopsy specimens from well-defined EMPD (13 of 810) were positive. Moreover, 4.6% of mapping biopsy specimens from ill-defined EMPD (8 of 165) were positive, whereas all specimens taken from sites 2 cm or more from the clinical border were negative. For both well-defined and ill-defined EMPD, there was no significant difference in the margin status of surgical resection regardless of mapping biopsy.LIMITATIONS:
This was a retrospective study.CONCLUSIONS:
Mapping biopsies are unnecessary for well-defined EMPD or when 2-cm margins can be achieved, whereas surgical removal with predetermined margins (1 cm for well-defined EMPD and 2 cm for ill-defined EMPD) appears to be safe. Mapping biopsies can be considered when shortening of the safe surgical margin to less than 2 cm is required in ill-defined EMPD.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Doença de Paget Extramamária
/
Margens de Excisão
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article