Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.

Liu, Lijun; Thaker, Tarjani M; Freed, Daniel M; Frazier, Nicole; Malhotra, Ketan; Lemmon, Mark A; Jura, Natalia

Liu, Lijun; Thaker, Tarjani M; Freed, Daniel M; Frazier, Nicole; Malhotra, Ketan; Lemmon, Mark A; Jura, Natalia.

Afiliação

Liu L; Cardiovascular Research Institute, University of California - San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California - San Francisco, San Francisco, CA 94158, USA.
Thaker TM; Cardiovascular Research Institute, University of California - San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California - San Francisco, San Francisco, CA 94158, USA.
Freed DM; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Cancer Biology Institute, Yale University, West Haven, CT 06516, USA.
Frazier N; Cardiovascular Research Institute, University of California - San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California - San Francisco, San Francisco, CA 94158, USA.
Malhotra K; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Cancer Biology Institute, Yale University, West Haven, CT 06516, USA.
Lemmon MA; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Cancer Biology Institute, Yale University, West Haven, CT 06516, USA.
Jura N; Cardiovascular Research Institute, University of California - San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California - San Francisco, San Francisco, CA 94158, USA. Electronic address: natalia.jura@ucsf.edu.

Structure ; 26(2): 270-281.e4, 2018 02 06.

Article em En | MEDLINE | ID: mdl-29358026

Assuntos

Proteínas de Caenorhabditis elegans/metabolismo; Receptores ErbB/metabolismo; Fosfotransferases/metabolismo; Transdução de Sinais/fisiologia; Animais; Caenorhabditis elegans; Dimerização; Fosforilação

Palavras-chave

EGFR; ERBB receptors; HER receptors; LET-23; allosteric kinase activation; asymmetric dimerization; kinase activation; kinase structure; receptor tyrosine kinase signaling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfotransferases / Transdução de Sinais / Proteínas de Caenorhabditis elegans / Receptores ErbB Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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