Improvement of chronic hepatitis B by iron chelation therapy in a patient with iron overload: A case report.
Medicine (Baltimore)
; 96(52): e9566, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29384977
ABSTRACT
RATIONALE This report describes seroconversion of hepatitis B surface antigen (HBsAg) in a patient with marked iron overload caused by chronic hepatitis B (CHB) after receiving iron chelation therapy and discusses the role of iron chelation therapy in CHB. PATIENT CONCERNS Increased serum ferritin level for 2 months. DIAGNOSIS Secondary iron overload and CHB. INTERVENTION To relieve iron load of the body, the patient underwent regular phlebotomy therapy and deferoxamine (DFO) therapy. During the therapy, serum ferritin and hepatitis B virus (HBV) were monitored and the iron concentration of the liver and heart were followed by T2* of magnetic resonance imaging (MRI) scan. OUTCOMES:
Serum ferritin gradually decreased. Approximately 1 year after the therapy, HBsAg turned persistently negative. LESSONS Iron chelation therapy may attenuate HBV infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia por Quelação
/
Sobrecarga de Ferro
/
Hepatite B Crônica
/
Desferroxamina
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article