Epigenetics and MicroRNAs in Cancer.
Int J Mol Sci
; 19(2)2018 Feb 03.
Article
em En
| MEDLINE
| ID: mdl-29401683
ABSTRACT
The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional structure of the genome is exploited by cancer cells to promote tumorigenesis. This reprogramming occurs because of hereditable chromatin chemical modifications and the consequent formation of RNA-protein-DNA complexes that represent the principal actors of the epigenetic phenomena. In this regard, the deregulation of a transcribed non-coding RNA may be both cause and consequence of a cancer-related epigenetic alteration. This review summarizes recent findings that implicate microRNAs in the aberrant epigenetic regulation of cancer cells.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
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Genoma Humano
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MicroRNAs
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Epigênese Genética
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Proteínas de Neoplasias
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Neoplasias
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Itália