Syncytial variant of nodular sclerosing Hodgkin lymphoma in children: A prognostic factor?
Pediatr Hematol Oncol
; 35(1): 33-36, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29420106
ABSTRACT
Nodular sclerosing Hodgkin lymphoma (HL) has an excellent prognosis in children. The syncytial variant (SV) of HL in adults represents a clinic pathologic entity with a worse outcome. We report the clinical features and the course of the disease of three children with refractory HL. The three patients with SV were analyzed in a retrospective multi-institutional study conducted in Israel in 51 children diagnosed with refractory or recurrent HL between 1997 and 2014. All the three children developed multiple recurrences soon after diagnosis. All three received at least three different chemotherapy combinations with autologous bone marrow transplantation for two patients, allogenic bone marrow transplantation in one, and immunotherapy in one. One patient died of disease, one is in complete response of the disease but developed a second metastatic malignancy, and one is alive without disease. This retrospective study shows that SV histology may be a prognostic factor for poor outcome in children diagnosed with HL.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença de Hodgkin
/
Transplante de Medula Óssea
/
Imunoterapia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Israel