Gastrodia elata alleviates mutant huntingtin aggregation through mitochondrial function and biogenesis mediation.

Huang, Chuen-Lin; Wang, Kaw-Chen; Yang, Ying-Chen; Chiou, Chun-Tang; Tan, Chia-Hui; Lin, Yun-Lian; Huang, Nai-Kuei

Huang, Chuen-Lin; Wang, Kaw-Chen; Yang, Ying-Chen; Chiou, Chun-Tang; Tan, Chia-Hui; Lin, Yun-Lian; Huang, Nai-Kuei.

Afiliação

Huang CL; Medical Research Center, Cardinal Tien Hospital, Hsintien, New Taipei City, Taiwan, ROC; Graduate Institute of Physiology & Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, ROC.
Wang KC; Department of Neurology, Cardinal-Tien Hospital, New Taipei City, Taiwan, ROC.
Yang YC; Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan, ROC.
Chiou CT; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan, ROC.
Tan CH; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan, ROC.
Lin YL; School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan, ROC.
Huang NK; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan, ROC; Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ROC. Electronic address: andrew@nricm.edu.tw.

Phytomedicine ; 39: 75-84, 2018 Jan 15.

Article em En | MEDLINE | ID: mdl-29433686

Assuntos

Medicamentos de Ervas Chinesas/farmacologia; Gastrodia/química; Proteína Huntingtina/genética; Mitocôndrias/efeitos dos fármacos; Antagonistas do Receptor A2 de Adenosina/farmacologia; Animais; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo; Medicamentos de Ervas Chinesas/administração & dosagem; Humanos; Proteína Huntingtina/metabolismo; Doença de Huntington/tratamento farmacológico; Doença de Huntington/genética; Mitocôndrias/metabolismo; Fármacos Neuroprotetores/farmacologia; Células PC12; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Fosforilação/efeitos dos fármacos; Regiões Promotoras Genéticas; Ratos

Palavras-chave

CREB; Gastrodia elata; Huntington's disease; Mitochondria; PGC-1α

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Gastrodia / Proteína Huntingtina / Mitocôndrias Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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