Belimumab and low-doses of mycophenolate mofetil as induction therapy of class IV lupus nephritis: case series and literature review.
BMC Nephrol
; 19(1): 54, 2018 03 07.
Article
em En
| MEDLINE
| ID: mdl-29514612
ABSTRACT
BACKGROUND:
The treatment of Lupus Nephritis (LN) is an unmet need in the management of patients with Systemic Lupus Erythematosus (SLE). CASE PRESENTATION We report two cases of women affected by Lupus Nephritis (LN) ISN/RNP Class IV with serological active disease, high disease activity and marked fatigue. In both cases, Mycophenolate mofetil (MMF), as induction therapy, was poorly tolerated because of gastrointestinal toxicity. Belimumab, together with low-doses of MMF, was effective as induction treatment leading to early achievement of complete renal response in these two selected cases of LN.CONCLUSIONS:
We also report a literature review concerning the efficacy and safety of Belimumab in Lupus Nephritis. Further studies are needed to evaluate the use of Belimumab to manage the renal involvement in patients with Systemic Lupus Erythematosus, waiting for the results of ongoing randomized clinical trials.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Nefrite Lúpica
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Anticorpos Monoclonais Humanizados
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Imunossupressores
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Antibióticos Antineoplásicos
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Ácido Micofenólico
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Itália