Subpopulations of T lymphocytes in Kenyan patients with visceral leishmaniasis.
Am J Trop Med Hyg
; 36(3): 497-500, 1987 May.
Article
em En
| MEDLINE
| ID: mdl-2953262
ABSTRACT
Populations of peripheral blood T lymphocytes from patients with Kenyan visceral leishmaniasis were studied using specifically defined antisera (monoclonal antibodies, Ortho-mune OKT3, OKT4, OKT6, and OKT8). The levels of total T lymphocytes and circulating thymocytes were within the same range as those of clinically normal individuals. However, the proportions of the helper/inducer T cells were lower in untreated patients than in the controls (18.9% vs. 39.7%) while the levels of suppressor/cytotoxic T cells were higher than in the controls (40.5% vs. 27.8%). After successful antileishmania treatment these levels showed a gradual return towards normal over a period of one year. It was concluded that immunosuppression observed is due to the levels of peripheral blood helper/inducer and suppressor/cytotoxic T lymphocytes.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
/
Linfócitos T Reguladores
/
Linfócitos T Auxiliares-Indutores
/
Leishmaniose Visceral
País/Região como assunto:
Africa
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article