Taxifolin prevents ß-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A<sub>2</sub>/prostaglandin E<sub>2</sub> content.

Wang, Yuanyuan; Wang, Qinwen; Bao, Xiaoming; Ding, Yanfei; Shentu, Jieyi; Cui, Wei; Chen, Xiaowei; Wei, Xiaofei; Xu, Shujun

Taxifolin prevents ß-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A₂/prostaglandin E₂ content.

Wang, Yuanyuan; Wang, Qinwen; Bao, Xiaoming; Ding, Yanfei; Shentu, Jieyi; Cui, Wei; Chen, Xiaowei; Wei, Xiaofei; Xu, Shujun.

Afiliação

Wang Y; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine Ningbo University, Ningbo, Zhejiang, 315211, China.
Wang Q; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine Ningbo University, Ningbo, Zhejiang, 315211, China.
Bao X; The No.2 Hospital of Ningbo, Ningbo, Zhejiang, 315010, China.
Ding Y; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine Ningbo University, Ningbo, Zhejiang, 315211, China.
Shentu J; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine Ningbo University, Ningbo, Zhejiang, 315211, China.
Cui W; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine Ningbo University, Ningbo, Zhejiang, 315211, China.
Chen X; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine Ningbo University, Ningbo, Zhejiang, 315211, China.
Wei X; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine Ningbo University, Ningbo, Zhejiang, 315211, China.
Xu S; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine Ningbo University, Ningbo, Zhejiang, 315211, China. xushujun@nbu.edu.cn.

Metab Brain Dis ; 33(4): 1069-1079, 2018 08.

Article em En | MEDLINE | ID: mdl-29542038

Assuntos

Peptídeos beta-Amiloides/metabolismo; Citosol/metabolismo; Dinoprostona/metabolismo; Transtornos da Memória/metabolismo; Fosfolipases A2/metabolismo; Quercetina/análogos & derivados; Sinapses/efeitos dos fármacos; Doença de Alzheimer/metabolismo; Animais; Linhagem Celular Tumoral; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Humanos; Masculino; Camundongos; Quercetina/farmacologia; Reconhecimento Psicológico/efeitos dos fármacos; Memória Espacial/efeitos dos fármacos; Sinapses/metabolismo

Palavras-chave

Alzheimer's disease; Cognitive impairments; Cytosolic phospholipase A2; Prostaglandin E2; Synapse; Taxifolin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quercetina / Sinapses / Dinoprostona / Peptídeos beta-Amiloides / Citosol / Fosfolipases A2 / Transtornos da Memória Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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