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Discovery and evaluation of nNav1.5 sodium channel blockers with potent cell invasion inhibitory activity in breast cancer cells.
Dutta, Shilpa; Lopez Charcas, Osbaldo; Tanner, Samuel; Gradek, Frédéric; Driffort, Virginie; Roger, Sébastien; Selander, Katri; Velu, Sadanandan E; Brouillette, Wayne.
Afiliação
  • Dutta S; Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, AL 35294-1240, USA; Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35294-1240, USA.
  • Lopez Charcas O; Inserm UMR1069, Nutrition, Croissance et Cancer, Université de Tours, Faculté de médecine, 10 Boulevard Tonnellé, 37032 Tours, Cedex, France.
  • Tanner S; Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, AL 35294-1240, USA; Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35294-1240, USA.
  • Gradek F; Inserm UMR1069, Nutrition, Croissance et Cancer, Université de Tours, Faculté de médecine, 10 Boulevard Tonnellé, 37032 Tours, Cedex, France.
  • Driffort V; Inserm UMR1069, Nutrition, Croissance et Cancer, Université de Tours, Faculté de médecine, 10 Boulevard Tonnellé, 37032 Tours, Cedex, France.
  • Roger S; Inserm UMR1069, Nutrition, Croissance et Cancer, Université de Tours, Faculté de médecine, 10 Boulevard Tonnellé, 37032 Tours, Cedex, France; Institut Universitaire de France, 1, rue Descartes, 75231 Paris Cedex 05, France.
  • Selander K; Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, 1808 7th Ave S, Birmingham, AL 35294-0012, USA.
  • Velu SE; Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, AL 35294-1240, USA; Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35294-1240, USA. Electronic address: svelu@uab.edu.
  • Brouillette W; Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, AL 35294-1240, USA; Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35294-1240, USA. Electronic address: wbrou@uab.edu.
Bioorg Med Chem ; 26(9): 2428-2436, 2018 05 15.
Article em En | MEDLINE | ID: mdl-29673714
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canal de Sódio Disparado por Voltagem NAV1.5 / Bloqueadores do Canal de Sódio Disparado por Voltagem / Invasividade Neoplásica / Antineoplásicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canal de Sódio Disparado por Voltagem NAV1.5 / Bloqueadores do Canal de Sódio Disparado por Voltagem / Invasividade Neoplásica / Antineoplásicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos