Crizotinib induces apoptosis and gene expression changes in ALK+ anaplastic large cell lymphoma cell lines; brentuximab synergizes and doxorubicin antagonizes.

Hudson, Sandra; Wang, Dongliang; Middleton, Frank; Nevaldine, Barbara H; Naous, Rana; Hutchison, Robert E

Hudson, Sandra; Wang, Dongliang; Middleton, Frank; Nevaldine, Barbara H; Naous, Rana; Hutchison, Robert E.

Afiliação

Hudson S; Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, New York.
Wang D; Department of Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, New York.
Middleton F; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York.
Nevaldine BH; Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, New York.
Naous R; Department of Pathology, SUNY Upstate Medical University, Syracuse, New York.
Hutchison RE; Department of Pathology, SUNY Upstate Medical University, Syracuse, New York.

Pediatr Blood Cancer ; 65(8): e27094, 2018 08.

Article em En | MEDLINE | ID: mdl-29697184

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Crizotinibe/farmacologia; Linfoma Anaplásico de Células Grandes/patologia; Brentuximab Vedotin; Linhagem Celular Tumoral; Doxorrubicina/farmacologia; Sinergismo Farmacológico; Expressão Gênica/efeitos dos fármacos; Humanos; Imunoconjugados/farmacologia; Terapia de Alvo Molecular/métodos; Inibidores de Proteínas Quinases/farmacologia

Palavras-chave

anaplastic large cell lymphoma; chemotherapy; molecular genetics; non-Hodgkin's lymphoma; pediatric oncology; tumor biology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Linfoma Anaplásico de Células Grandes / Crizotinibe / Antineoplásicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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