Trade-off of cerebello-cortical and cortico-cortical functional networks for planning in 6-year-old children.
Neuroimage
; 176: 510-517, 2018 08 01.
Article
em En
| MEDLINE
| ID: mdl-29730492
ABSTRACT
Childhood is a critical period for the development of cognitive planning. There is a lack of knowledge on its neural mechanisms in children. This study aimed to examine cerebello-cortical and cortico-cortical functional connectivity in association with planning skills in 6-year-olds (nâ¯=â¯76). We identified the cerebello-cortical and cortico-cortical functional networks related to cognitive planning using activation likelihood estimation (ALE) meta-analysis on existing functional imaging studies on spatial planning, and data-driven independent component analysis (ICA) of children's resting-state functional MRI (rs-fMRI). We investigated associations of cerebello-cortical and cortico-cortical functional connectivity with planning ability in 6-year-olds, as assessed using the Stockings of Cambridge task. Long-range functional connectivity of two cerebellar networks (lobules VI and lateral VIIa) with the prefrontal and premotor cortex were greater in children with poorer planning ability. In contrast, cortico-cortical association networks were not associated with the performance of planning in children. These results highlighted the key contribution of the lateral cerebello-frontal functional connectivity, but not cortico-cortical association functional connectivity, for planning ability in 6-year-olds. Our results suggested that brain adaptation to the acquisition of planning ability during childhood is partially achieved through the engagement of the cerebello-cortical functional connectivity.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Desempenho Psicomotor
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Cerebelo
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Córtex Cerebral
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Desenvolvimento Infantil
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Função Executiva
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Conectoma
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Rede Nervosa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Singapura