Your browser doesn't support javascript.
loading
[12]aneN3-based lipid with naphthalimide moiety for enhanced gene transfection efficiency.
Gao, Yong-Guang; Alam, Uzair; Ding, Ai-Xiang; Tang, Quan; Tan, Zheng-Li; Shi, You-Di; Lu, Zhong-Lin; Qian, Ai-Rong.
Afiliação
  • Gao YG; Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China; Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing No
  • Alam U; Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China.
  • Ding AX; Xinyang Normal University, Xinyang, Henan 464000, China.
  • Tang Q; Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China.
  • Tan ZL; Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China.
  • Shi YD; Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China.
  • Lu ZL; Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China. Electronic address: luzl@bnu.edu.cn.
  • Qian AR; Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China. Electronic address: qianair@nwpu.edu.cn.
Bioorg Chem ; 79: 334-340, 2018 09.
Article em En | MEDLINE | ID: mdl-29803080
ABSTRACT
Three cationic lipids derived from [12]aneN3 modified with naphthalimide (1a), oleic acid (1b) and octadecylamine (1c) were designed and synthesized. In vitro transfection showed that all these liposomes can deliver plasmid DNA into the tested cell lines. Among these liposomes, 1a gave the best transfection efficiency (TE) in A549 cells, which was higher than that of lipofectamine 2000. More importantly, the TE of 1a was dramatically increased in the presence of 10% serum. These results suggested that 1a might be a promising non-viral gene vector, and also give further insight for developing novel high performance gene delivery agents.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas de Transferência de Genes / Naftalimidas / Lipídeos / Luciferases Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas de Transferência de Genes / Naftalimidas / Lipídeos / Luciferases Idioma: En Ano de publicação: 2018 Tipo de documento: Article