Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae.
J Nat Prod
; 81(6): 1444-1450, 2018 06 22.
Article
em En
| MEDLINE
| ID: mdl-29878761
ABSTRACT
A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 µM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polyporaceae
/
Sesquiterpenos
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Terpenos
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Citotoxinas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article