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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.
Londregan, Allyn T; Wei, Liuqing; Xiao, Jun; Lintner, Nathanael G; Petersen, Donna; Dullea, Robert G; McClure, Kim F; Bolt, Michael W; Warmus, Joseph S; Coffey, Steven B; Limberakis, Chris; Genovino, Julien; Thuma, Benjamin A; Hesp, Kevin D; Aspnes, Gary E; Reidich, Benjamin; Salatto, Christopher T; Chabot, Jeffrey R; Cate, Jamie H D; Liras, Spiros; Piotrowski, David W.
Afiliação
  • Londregan AT; Pfizer Medicinal Chemistry , Groton , Connecticut 06340 , United States.
  • Wei L; Pfizer Medicinal Chemistry , Groton , Connecticut 06340 , United States.
  • Xiao J; Pfizer Medicinal Chemistry , Groton , Connecticut 06340 , United States.
  • Lintner NG; Department of Molecular and Cell Biology , University of California, Berkeley , Berkeley , California 94720 , United States.
  • Petersen D; Primary Pharmacology Group, Pharmacokinetics, Dynamics and Metabolism , Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States.
  • Dullea RG; Internal Medicine Research Unit , Pfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , United States.
  • McClure KF; Pfizer Medicinal Chemistry, Internal Medicine Research Unit , Pfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , United States.
  • Bolt MW; Drug Safety Research & Development , Pfizer Worldwide Research & Development , Cambridge , Massachusetts 02139 , United States.
  • Warmus JS; Pfizer Medicinal Chemistry , Groton , Connecticut 06340 , United States.
  • Coffey SB; Pfizer Medicinal Chemistry , Groton , Connecticut 06340 , United States.
  • Limberakis C; Pfizer Medicinal Chemistry , Groton , Connecticut 06340 , United States.
  • Genovino J; Pfizer Medicinal Chemistry , Groton , Connecticut 06340 , United States.
  • Thuma BA; Pfizer Medicinal Chemistry , Groton , Connecticut 06340 , United States.
  • Hesp KD; Pfizer Medicinal Chemistry , Groton , Connecticut 06340 , United States.
  • Aspnes GE; Pfizer Medicinal Chemistry, Internal Medicine Research Unit , Pfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , United States.
  • Reidich B; Internal Medicine Research Unit , Pfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , United States.
  • Salatto CT; Internal Medicine Research Unit , Pfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , United States.
  • Chabot JR; Pfizer Pharmacokinetics, Dynamics and Metabolism Modeling and Simulation , Pfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , United States.
  • Cate JHD; Department of Molecular and Cell Biology , University of California, Berkeley , Berkeley , California 94720 , United States.
  • Liras S; QB3 Institute , University of California, Berkeley , Berkeley , California 94720 , United States.
  • Piotrowski DW; Department of Chemistry , University of California, Berkeley , Berkeley , California 94720 , United States.
J Med Chem ; 61(13): 5704-5718, 2018 07 12.
Article em En | MEDLINE | ID: mdl-29878763
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Inibidores de PCSK9 Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Inibidores de PCSK9 Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos