Optimization of a combined wet milling process in order to produce poly(vinyl alcohol) stabilized nanosuspension.
Drug Des Devel Ther
; 12: 1567-1580, 2018.
Article
em En
| MEDLINE
| ID: mdl-29910603
ABSTRACT
PURPOSE:
The article reports a wet milling process, where the planetary ball mill was combined with pearl milling technology to reach nanosize range of meloxicam (Mel; 100-500 nm). The main purpose was to increase the dissolution rate and extent of a poorly water-soluble Mel as nonsteroidal anti-inflammatory drug as well as to study its permeability across cultured intestinal epithelial cell layers.METHODS:
Viscosity of milled dispersion and particle size distribution and zeta potential of Mel were investigated and differential scanning calorimeter and X-ray powder diffractometer were used to analyse the structure of the suspended Mel. Finally in vitro dissolution test and in vitro cell culture studies were made.RESULTS:
It was found that the ratio of predispersion and pearls 11 (w/w) resulted in the most effective grinding system (200-fold particle size reduction in one step) with optimized process parameters, 437 rpm and 43 min. Nanosuspension (1% Mel and 0.5% poly[vinyl alcohol]) as an intermediate product showed a stable system with 2 weeks of holding time. This optimized nanosuspension enhanced the penetration of Mel across cultured intestinal epithelial cell layers without toxic effects.CONCLUSION:
The dissolution rate of Mel from the poly(vinyl alcohol) stabilized nanosuspension justified its applicability in the design of innovative per oral dosage form (capsule) in order to ensure/give a rapid analgesia.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Álcool de Polivinil
/
Tiazinas
/
Tiazóis
/
Tecnologia Farmacêutica
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Hungria