Anti-rheumatic medication and salivary MMP-8, a biomarker for periodontal disease.
Oral Dis
; 24(8): 1562-1571, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-29969841
ABSTRACT
OBJECTIVE:
To investigate the impact of anti-rheumatic medications on salivary matrix metalloproteinase (MMP)-8 levels and MMP-8/TIMP (tissue inhibitor of MMPs)-1 ratio in patients with rheumatoid arthritis (RA) and periodontal findings during a 1-year follow-up. MATERIALS ANDMETHODS:
Salivary MMP-8 was measured by an immunofluorometric assay and TIMP-1 by an enzyme-linked immunosorbent assay of 53 patients with early untreated RA (ERA), naïve to synthetic disease modifying anti-rheumatic drugs (DMARDs), of 28 patients with chronic RA (CRA), candidates for biologic DMARDs and of 43 age- and sex-matched controls. Periodontal health was evaluated by bleeding on probing (BOP), pocket depth (PD), and periodontal inflammatory burden index (PIBI). Examinations were conducted twice for RA patients and once for controls.RESULTS:
Salivary MMP-8 level and MMP-8/TIMP-1 ratio associated positively with PIBI in patients with chronic RA (MMP-8 p < 0.001 at baseline, p = 0.002 after follow-up; MMP-8/TIMP-1 ratio p < 0.001, p = 0.003, respectively) and in controls (MMP-8 p = 0.010, MMP-8/TIMP-1 ratio p = 0.010). Salivary MMP-8 levels were highest at the early stage of RA. The used DMARDs, synthetic or biologic, did not affect salivary MMP-8 concentrations.CONCLUSIONS:
The use of synthetic or biologic DMARDs did not affect salivary MMP-8 levels in RA patients regardless the duration of RA.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças Periodontais
/
Saliva
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Antirreumáticos
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Inibidor Tecidual de Metaloproteinase-1
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Metaloproteinase 8 da Matriz
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Finlândia