Hybrid Nanoreactors: Enabling an Off-the-Shelf Strategy for Concurrently Enhanced Chemo-immunotherapy.
Angew Chem Int Ed Engl
; 57(36): 11764-11769, 2018 09 03.
Article
em En
| MEDLINE
| ID: mdl-30014609
ABSTRACT
Immunosuppressive tumors generally exhibit poor response to immune checkpoint blockade based cancer immunotherapy. Rationally designed hybrid nanoreactors are now presented that have integrated functions as Fenton catalysts and glutathione depletion agents for amplifying the immunogenic cell death and activating immune cells. A simple physical mixture of nanoreactors and chemodrugs in combination with immune checkpoint blockades show synergistically and concurrently enhanced chemo-immunotherapy efficacy, inhibiting the growth of both treated primary immunosuppressive tumors and untreated distant tumors. The off-the-shelf strategy uses tumor antigens generated inâ
situ and avoids cargo loading, and is thus a substantial advance in personalized nanomedicine for clinical translation.
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Base de dados:
MEDLINE
Assunto principal:
Doxorrubicina
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Nanomedicina
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Peróxido de Hidrogênio
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Imunoterapia
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Ferro
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Antibióticos Antineoplásicos
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Neoplasias
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Austrália