Atherosclerosis and renal disease involvement in patients with systemic lupus erythematosus: a cross-sectional cohort study.
Rheumatology (Oxford)
; 57(11): 1964-1971, 2018 11 01.
Article
em En
| MEDLINE
| ID: mdl-30016488
ABSTRACT
Objective:
To investigate the association between LN, renal function and atherosclerosis measured by coronary artery calcium (CAC) and carotid plaque in a cross-sectional study of patients with SLE.Methods:
Presence of CAC and carotid plaque was measured in 147 SLE patients with and without LN. The patients were divided into four groups according to LN and renal function [by first quartile of estimated glomerular filtration rate (eGFR) 70 ml/min/1.73 m2]. Impaired renal function was defined by an eGFR <70 ml/min/1.73 m2. We used multivariate logistic regression models to explore the association between LN, renal function, CAC and carotid plaque.Results:
Of the 147 SLE patients, 74 had LN. Median age of the study cohort was 46 years, 89% were women and median eGFR was 89 ml/min/1.73 m2. CAC score >0 was present in 57 (39%) and carotid plaque in 29 (20%) of the SLE patients. The presence of CAC and/or carotid plaque was highest in SLE patients with impaired renal function. Regression analyses showed that compared with SLE patients without LN and eGFR ⩾70 ml/min/1.73 m2 (reference group), only the combination of LN and impaired renal function was associated with the presence of CAC (odds ratio 6.82, 95% CI 1.59, 29; P = 0.01) and carotid plaque (odds ratio 5.60, 95% CI 1.19, 26; P = 0.03).Conclusion:
Our findings indicate that LN in combination with impaired renal function defined by an eGFR <70 ml/min/1.73 m2 is strongly associated with the presence of atherosclerosis in SLE.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aterosclerose
/
Nefropatias
/
Lúpus Eritematoso Sistêmico
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Dinamarca