Enteric nervous system development: what could possibly go wrong?
Nat Rev Neurosci
; 19(9): 552-565, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30046054
ABSTRACT
The gastrointestinal tract contains its own set of intrinsic neuroglial circuits - the enteric nervous system (ENS) - which detects and responds to diverse signals from the environment. Here, we address recent advances in the understanding of ENS development, including how neural-crest-derived progenitors migrate into and colonize the bowel, the formation of ganglionated plexuses and the molecular mechanisms of enteric neuronal and glial diversification. Modern lineage tracing and transcription-profiling technologies have produced observations that simultaneously challenge and affirm long-held beliefs about ENS development. We review many genetic and environmental factors that can alter ENS development and exert long-lasting effects on gastrointestinal function, and discuss how developmental defects in the ENS might account for some of the large burden of digestive disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Entérico
/
Trato Gastrointestinal
/
Neurônios
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos