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Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis.
Strnad, Pavel; Buch, Stephan; Hamesch, Karim; Fischer, Janett; Rosendahl, Jonas; Schmelz, Renate; Brueckner, Stefan; Brosch, Mario; Heimes, Carolin V; Woditsch, Vivien; Scholten, David; Nischalke, Hans Dieter; Janciauskiene, Sabina; Mandorfer, Mattias; Trauner, Michael; Way, Michael J; McQuillin, Andrew; Reichert, Matthias C; Krawczyk, Marcin; Casper, Markus; Lammert, Frank; Braun, Felix; von Schönfels, Witigo; Hinz, Sebastian; Burmeister, Greta; Hellerbrand, Claus; Teufel, Andreas; Feldman, Alexandra; Schattenberg, Joern M; Bantel, Heike; Pathil, Anita; Demir, Muenevver; Kluwe, Johannes; Boettler, Tobias; Ridinger, Monika; Wodarz, Norbert; Soyka, Michael; Rietschel, Marcella; Kiefer, Falk; Weber, Thomas; Marhenke, Silke; Vogel, Arndt; Hinrichsen, Holger; Canbay, Ali; Schlattjan, Martin; Sosnowsky, Katharina; Sarrazin, Christoph; von Felden, Johann; Geier, Andreas; Deltenre, Pierre.
Afiliação
  • Strnad P; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Buch S; Coordinating Center for Alpha1-antitrypsin Deficiency-related Liver Disease of the European Reference Network (ERN) 'Rare Liver', European Association for the Study of the Liver (EASL) Registry Group 'Alpha1-Liver', Aachen, Germany.
  • Hamesch K; Medical Department 1, University Hospital Dresden, Dresden, Germany.
  • Fischer J; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Rosendahl J; Coordinating Center for Alpha1-antitrypsin Deficiency-related Liver Disease of the European Reference Network (ERN) 'Rare Liver', European Association for the Study of the Liver (EASL) Registry Group 'Alpha1-Liver', Aachen, Germany.
  • Schmelz R; Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany.
  • Brueckner S; Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany.
  • Brosch M; Department of Internal Medicine I, University Hospital Halle, Martin Luther University, Halle, Germany.
  • Heimes CV; Medical Department 1, University Hospital Dresden, Dresden, Germany.
  • Woditsch V; Medical Department 1, University Hospital Dresden, Dresden, Germany.
  • Scholten D; Medical Department 1, University Hospital Dresden, Dresden, Germany.
  • Nischalke HD; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Janciauskiene S; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Mandorfer M; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Trauner M; Department of Internal Medicine I, University of Bonn, Bonn, Germany.
  • Way MJ; Clinic for Pneumology, German Center for Lung Research (DZL), Medical University Hannover, Hannover, Germany.
  • McQuillin A; Clinic for Gastroenterology und Hepatology, Medical University Vienna, Vienna, Austria.
  • Reichert MC; Clinic for Gastroenterology und Hepatology, Medical University Vienna, Vienna, Austria.
  • Krawczyk M; Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, UK.
  • Casper M; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
  • Lammert F; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
  • Braun F; Department of Medicine II, Saarland University Medical Center, Homburg, Germany.
  • von Schönfels W; Department of Medicine II, Saarland University Medical Center, Homburg, Germany.
  • Hinz S; Laboratory of Metabolic Liver Diseases, Department of General, Transplantation and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
  • Burmeister G; Department of Medicine II, Saarland University Medical Center, Homburg, Germany.
  • Hellerbrand C; Department of Medicine II, Saarland University Medical Center, Homburg, Germany.
  • Teufel A; Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Feldman A; Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Schattenberg JM; Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Bantel H; Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Pathil A; Institute of Biochemistry, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Demir M; Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.
  • Kluwe J; Department of Internal Medicine I, University Hospital Salzburg, Salzburg, Austria.
  • Boettler T; Department of Medicine I, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany.
  • Ridinger M; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Wodarz N; Department of Internal Medicine IV, Gastroenterology and Hepatology, University of Heidelberg, Heidelberg, Germany.
  • Soyka M; Clinic for Gastroenterology and Hepatology, University Hospital of Cologne, Cologne, Germany.
  • Rietschel M; I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Kiefer F; Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
  • Weber T; Department of Psychology, University of Konstanz, Konstanz, Germany.
  • Marhenke S; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
  • Vogel A; Psychiatric Hospital, Ludwig Maximilians University, Munich, Germany.
  • Hinrichsen H; Faculty of Medicine Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Canbay A; Faculty of Medicine Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Schlattjan M; Department for Clinical Research, University Hospital Bern, Bern, Switzerland.
  • Sosnowsky K; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Sarrazin C; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • von Felden J; Department of Gastroenterology, University Hospital Kiel, Kiel, Germany.
  • Geier A; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany.
  • Deltenre P; Department of Gastroenterology and Hepatology, University Duisburg-Essen, Essen, Germany.
Gut ; 68(6): 1099-1107, 2019 06.
Article em En | MEDLINE | ID: mdl-30068662
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alfa 1-Antitripsina / Predisposição Genética para Doença / Heterozigoto / Cirrose Hepática Alcoólica País/Região como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alfa 1-Antitripsina / Predisposição Genética para Doença / Heterozigoto / Cirrose Hepática Alcoólica País/Região como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha