MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct.

Jain, Ruchi; Frederick, Josh P; Huang, Eric Y; Burke, Kristine E; Mauger, David M; Andrianova, Elizaveta A; Farlow, Sam J; Siddiqui, Summar; Pimentel, Jeffrey; Cheung-Ong, Kahlin; McKinney, Kristine M; Köhrer, Caroline; Moore, Melissa J; Chakraborty, Tirtha

Jain, Ruchi; Frederick, Josh P; Huang, Eric Y; Burke, Kristine E; Mauger, David M; Andrianova, Elizaveta A; Farlow, Sam J; Siddiqui, Summar; Pimentel, Jeffrey; Cheung-Ong, Kahlin; McKinney, Kristine M; Köhrer, Caroline; Moore, Melissa J; Chakraborty, Tirtha.

Afiliação

Jain R; 1 Department of Molecular Biology, Moderna Therapeutics , Cambridge, Massachusetts.
Frederick JP; 2 Department of Oncology, Moderna Therapeutics , Cambridge, Massachusetts.
Huang EY; 3 New Venture Labs , Moderna Therapeutics, Cambridge, Massachusetts.
Burke KE; 4 Non-Clinical Sciences , Moderna Therapeutics, Cambridge, Massachusetts.
Mauger DM; 5 Computational Sciences , Moderna Therapeutics, Cambridge, Massachusetts.
Andrianova EA; 1 Department of Molecular Biology, Moderna Therapeutics , Cambridge, Massachusetts.
Farlow SJ; 2 Department of Oncology, Moderna Therapeutics , Cambridge, Massachusetts.
Siddiqui S; 6 Rare Diseases , Moderna Therapeutics, Cambridge, Massachusetts.
Pimentel J; 6 Rare Diseases , Moderna Therapeutics, Cambridge, Massachusetts.
Cheung-Ong K; 2 Department of Oncology, Moderna Therapeutics , Cambridge, Massachusetts.
McKinney KM; 3 New Venture Labs , Moderna Therapeutics, Cambridge, Massachusetts.
Köhrer C; 1 Department of Molecular Biology, Moderna Therapeutics , Cambridge, Massachusetts.
Moore MJ; 1 Department of Molecular Biology, Moderna Therapeutics , Cambridge, Massachusetts.
Chakraborty T; 1 Department of Molecular Biology, Moderna Therapeutics , Cambridge, Massachusetts.

Nucleic Acid Ther ; 28(5): 285-296, 2018 10.

Article em En | MEDLINE | ID: mdl-30088967

Assuntos

Carcinoma Hepatocelular/genética; Neoplasias Hepáticas/genética; MicroRNAs/genética; RNA Mensageiro/genética; Animais; Apoptose/genética; Proteínas Reguladoras de Apoptose/genética; Carcinoma Hepatocelular/patologia; Carcinoma Hepatocelular/terapia; Caspases/genética; Regulação Neoplásica da Expressão Gênica/genética; Células HeLa; Hepatócitos/metabolismo; Humanos; Neoplasias Hepáticas/patologia; Neoplasias Hepáticas/terapia; Camundongos; MicroRNAs/uso terapêutico; Cultura Primária de Células; Proteínas Proto-Oncogênicas/genética; Células RAW 264.7; RNA Mensageiro/uso terapêutico

Palavras-chave

RNA modifications; mRNA; miRNA; suicide therapy; therapeutic

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Carcinoma Hepatocelular / MicroRNAs / Neoplasias Hepáticas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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