Local and systemic levels of cytokines and danger signals in endometriosis-affected women.
J Reprod Immunol
; 130: 7-10, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30099220
ABSTRACT
Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called 'danger theory' related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammation is linked to the severity of the disease. In addition, we investigated the role of recently described cytokines IL-33, IL-32α and the 'alarmin' high mobility group box 1 (HMGB1). We confirmed a dysfunctional immune response in the local environment of women suffering from endometriosis. However, we found no direct evidence for a significant up-regulation of danger signals in endometriosis, irrespective of the severity of the disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína HMGB1
/
Endometriose
/
Alarminas
/
Interleucina-33
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Áustria