Engineering the protein secretory pathway of <i>Saccharomyces cerevisiae</i> enables improved protein production.

Huang, Mingtao; Wang, Guokun; Qin, Jiufu; Petranovic, Dina; Nielsen, Jens

Engineering the protein secretory pathway of Saccharomyces cerevisiae enables improved protein production.

Huang, Mingtao; Wang, Guokun; Qin, Jiufu; Petranovic, Dina; Nielsen, Jens.

Afiliação

Huang M; Department of Biology and Biological Engineering, Chalmers University of Technology, SE41296 Gothenburg, Sweden.
Wang G; Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, SE41296 Gothenburg, Sweden.
Qin J; Department of Biology and Biological Engineering, Chalmers University of Technology, SE41296 Gothenburg, Sweden.
Petranovic D; Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, SE41296 Gothenburg, Sweden.
Nielsen J; Department of Biology and Biological Engineering, Chalmers University of Technology, SE41296 Gothenburg, Sweden.

Proc Natl Acad Sci U S A ; 115(47): E11025-E11032, 2018 11 20.

Article em En | MEDLINE | ID: mdl-30397111

Assuntos

Engenharia Metabólica/métodos; Biossíntese de Proteínas/genética; Proteínas Recombinantes/metabolismo; Saccharomyces cerevisiae/metabolismo; Via Secretória/fisiologia; alfa-Amilases/biossíntese; Endossomos/metabolismo; Complexo de Golgi/metabolismo; Histona Desacetilases/genética; Transporte Proteico/genética; Proteínas Recombinantes/genética; Saccharomyces cerevisiae/genética; Via Secretória/genética

Palavras-chave

cell engineering; endosome-to-Golgi trafficking; intracellular protein retention; protein secretion; yeast cell factories

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Biossíntese de Proteínas / Proteínas Recombinantes / Alfa-Amilases / Via Secretória / Engenharia Metabólica Idioma: En Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suécia

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