MicroRNA-621 Acts as a Tumor Radiosensitizer by Directly Targeting SETDB1 in Hepatocellular Carcinoma.

Shao, Yingjie; Song, Xing; Jiang, Wenjie; Chen, Yuan; Ning, Zhonghua; Gu, Wendong; Jiang, Jingting

Shao, Yingjie; Song, Xing; Jiang, Wenjie; Chen, Yuan; Ning, Zhonghua; Gu, Wendong; Jiang, Jingting.

Afiliação

Shao Y; Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China.
Song X; Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China.
Jiang W; Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China.
Chen Y; Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China.
Ning Z; Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China.
Gu W; Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China. Electronic address: guwendong1415@czfph.com.
Jiang J; Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou 213003, China. Electronic address: jiangjingting@suda.edu.cn.

Mol Ther ; 27(2): 355-364, 2019 02 06.

Article em En | MEDLINE | ID: mdl-30503969

Assuntos

Carcinoma Hepatocelular/metabolismo; Histona-Lisina N-Metiltransferase/metabolismo; Neoplasias Hepáticas/metabolismo; MicroRNAs/metabolismo; Micro-Ondas; Radiossensibilizantes/metabolismo; Animais; Carcinoma Hepatocelular/radioterapia; Linhagem Celular Tumoral; Proliferação de Células/genética; Proliferação de Células/efeitos da radiação; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/genética; Células Hep G2; Histona-Lisina N-Metiltransferase/genética; Humanos; Neoplasias Hepáticas/radioterapia; Camundongos; Camundongos Nus; MicroRNAs/genética; Transdução de Sinais/genética; Transdução de Sinais/efeitos da radiação

Palavras-chave

SETDB1; hepatocellular carcinoma; miR-621; p53; radiosensitivity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radiossensibilizantes / Histona-Lisina N-Metiltransferase / Carcinoma Hepatocelular / MicroRNAs / Neoplasias Hepáticas / Micro-Ondas Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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